We recently reported that HFD feeding induces hyperglycemia in InsrP1195L/+/HFD mice through increased lipolysis and increased gluconeogenesis from glycerol.3 Interestingly, abnormal upregulation of G6pc, the critical regulator of gluconeogenesis, was significantly ameliorated in the InsrP1195L/+/HFD liver by EPA supplementation. The gene discussed is G6PC1; the disease is Hyperglycemia.