INS and obesity due to melanocortin 4 receptor deficiency: Adiposity is known to influence release of adipocytokines from WAT to mediate insulin sensitivity.23 Especially, adiponectin has been shown to improve insulin sensitivity in various insulin target tissues, such as liver and skeletal muscle,24 and to be decreased in obesity and T2DM.13 Nevertheless, InsrP1195L/+/HFD mice exhibited lower adiponectin levels compared with those of WT/HFD mice despite the lower body weight.