Although gluconeogenesis from glycerol was increased in InsrP1195L/+/HFD mice, as previously reported,3 the blood glucose rise after glycerol administration was significantly attenuated in InsrP1195L/+/HFD+EPA mice, suggesting that EPA supplementation may ameliorate hyperglycemia through suppression of G6pc expression. This evidence concerns the gene G6PC1 and Hyperglycemia.