Adiponectin has been reported to suppress gluconeogenesis through both AMPK signaling-dependent and -independent pathways.24, 25 Accordingly, in the InsrP1195L/+/HFD liver, decreased adiponectin levels could elicit the increase in gluconeogenesis in the liver and lead to the development of hyperglycemia. This evidence concerns the gene ADIPOQ and Hyperglycemia.