CXCL2 and neoplasm: Importantly, tumor cells themselves can promote neutrophil recruitment to the TME [26], and IL-8, or its murine functional homologs CXCL1 (KC) and CXCL2 (MIP-2), have been shown to attract neutrophils to the TME in preclinical models of Ras-driven cancer [27,28,29].