The rs5219 SNP—which causes the K23E substitution in KCNJ11 gene (Figure S3)—maps to the consensus of the nuclear receptor PPARγ, and it is predicted to alter the binding affinity of this TF, a crucial player in glucose and lipid homeostasis and that is associated with metabolic disorders [19]. The gene discussed is KCNJ11; the disease is Other metabolic disease.