PPARβ/δ seems to be implicated in the development of colon cancer [52]; a potential explanation of this association is that the activation of PPARβ/δ by arachidonic acid causes the up-regulation of cyclooxygenase (COX-2) and the over-production of prostaglandin (PG-E2), which have key roles as activators of colon cancer cells [52]. This evidence concerns the gene PPARD and malignant colon neoplasm.