Evidence has revealed that the absence of TLR4 genes in the liver reduces liver IR injury [6,7,8,9,10,11,12], and TLR4 blockade affects the function of hepatocytes and Kupffer cells, depresses the production of proinflammatory cytokines (TNF-α and IL-6) and ameliorates hepatocellular IR injury [6]. The gene discussed is TNF; the disease is digestive system neoplasm.