In respect to Ang II, a recent study using a model of cardiac remodeling in hypertension salt-insensitive, guanylyl cyclase-A knockout mice [110] showed that chronic treatment with the MR antagonist eplerenone reduced the amount of brain and atrial natriuretic peptide, hypertrophy markers, and cardiac fibrosis markers, including TGF-β, collagen I, and collagen III. Here, AGT is linked to hypertensive disorder.