EDN1 and Cerebral ischemia: In the study by Jones et al where cerebral ischemia was initiated in monkeys by ligating the MCA, the average CBF after ligation in the insular cortex was 17 ± 16 mL·min-1·100g-1 [28], in this study the average CBF across all animals and time points after the first ET-1 injection was 15 ± 5 mL·min-1·100g-1.