VWA1 and tuberculosis: Pvs28 and pvs25 showed higher genetic variability compared to other sexual stage TB antigens reported in P. vivax as pvs48/45 (π = 0,00053), the Willebrand factor A domain-related protein (WARP) (π = 0.00010) and also previous estimations of pvs25 (π = 0.00065) and pvs28 (π = 0.00000) in Korea [50].