Meanwhile, a common variant in the regulatory ‘promoter’ region of the UCP3 gene (the presence of a thymidine base rather than the more frequent cytosine: −55C>T, rs1800849) is in negative LD with the UCP2 D/I polymorphism 48, the T allele being associated with obesity in a recessive manner 48 and with higher circulating low‐density lipoproteins cholesterol levels 49. Here, UCP2 is linked to obesity due to melanocortin 4 receptor deficiency.