Considering UCP3, the ACE activity for CC versus CT versus TT genotypes was 53·0 ± 17·0 versus 49·5 ± 18·3 versus 45·5 ± 16·6 nmol his‐leu/ml/min (P = 0·02 ANOVA) in the T1DM cohort. This evidence concerns the gene ACE and type 1 diabetes mellitus.