TACR3 and cocaine dependence: Certain additional TACR3 polymorphisms, such as A29V, G59E, S455G, A449S, W275X, and rs4580655, have been associated with idiopathic central pubertal disorders [23, 24], predicting and improving learning and memory in aged organism [25], alcohol and cocaine dependence [26], and pediatric slow transit constipation [27].