LGMD-causing genes encode proteins that belong to several different cellular pathways, including sarcolemmal glycoproteins (dystroglycan and sarcoglycans), scaffolding proteins (caveolin-3 (CAV3)), membrane repair and vesicle trafficking proteins (dysferlin (DYSF)) and nuclear envelope proteins (lamin A/C (LMNA)) [35]. The gene discussed is DYSF; the disease is limb-girdle muscular dystrophy.