However, there was no significant difference in the frequency of TP53 mutation between DLBCL with an isolated MYC translocation and those with double translocations (MYC plus BCL2 or BCL6) (14/35 = 40% versus 13/46 = 28.3%, p = 0.38). The gene discussed is BCL2; the disease is diffuse large B-cell lymphoma.