Following arthritis onset, DR3−/− LY6G+ neutrophil signal in the aorta was significantly (P < 0.05) increased in comparison with arthritic DR3WT mice (1.8 ± 0.5%, n = 4 vs. 0.4 ± 0.2, n = 6) (Fig. 4). The gene discussed is TNFRSF25; the disease is arthritic joint disease.