Two other key intracellular sensors of RNA and DNA may also play a role in the pathogenesis of autoimmune diseases such as primary Sjögren’s syndrome, namely the retinoic acid-inducible gene I (RIG-I)-like receptors RIG-I and Mda5 and cyclic GMP-AMP synthase/STING, respectively, which also activate the production of type 1 IFN38. This evidence concerns the gene RIGI and Sjogren syndrome.