Treatment of tumor cells with vorinostat has been shown to downregulate transcription of DNA methyltransferases DNMT1 and DNMT3b in the A549 lung cancer line and to induce methylation changes in important cancer-related genes such as human telomerase reverse transcriptase (TERT, or hTERT) and “deleted in liver cancer” (DLC1) [36–38]. Here, DNMT1 is linked to cancer.