CRP and coronary artery disorder: Yeboah et al., have reported improvement in the Framingham Risk Score for prediction of CHD within intermediate-risk participants using additional risk markers; nevertheless, the net reclassification improvement for incident CHD with high-sensitivity CRP was less than coronary artery calcium, brachial flow-mediated dilation, ankle-brachial index, carotid intima-media thickness and family history [58].