NKX2-5 and heart failure: In contrast, we found that overexpressed Myc bound both the promoter region and body of many cardiac-specific genes including transcription factors (Gata4, Gata6, Tbx20, Nkx2-5), structural genes (Actc1, Pln), or heart failure related genes (Nppa, Nppb), but did not induce Pol II recruitment (Fig. S3A).