A recent prospective study involving 77,680 persons (from 2 large prospective studies of the Danish general population, the CCHS; Copenhagen City Heart Study and the CGPS; Copenhagen General Population Study), demonstrated that increased Lp(a) levels and corresponding 3 LPA genetic variants (all associated with Lp(a) levels) were associated with increased risk of aortic stenosis in the general population, with lev-els>90 mg/dL predicting a threefold increased risk[51]. The gene discussed is LPA; the disease is aortic stenosis.