RIOK1 and RIOK2 are overexpressed in glioblastoma cells in an Akt-dependent manner, and down-regulated expression of RIOK1 or RIOK2 disrupts Akt signalling and causes cell cycle exit, apoptosis, and chemosensitivity in glioblastoma cells by inducing p53 activity27. Here, RIOK1 is linked to glioblastoma.