As shown in the Kaplan–Meier survival curves (Fig. 5), NSCLC patients who presented with high RIOK2 or NOB1 expression had poor overall survival rates compared with patients who presented with low expression (RIOK2: P < 0.001; NOB1: P = 0.001), and patients who presented with high expression levels of both RIOK2 and NOB1 had poorer overall survival rates compared with patients who presented with low expression levels of RIOK2 or NOB1 (P < 0.001). Here, RIOK2 is linked to non-small cell lung carcinoma.