RIOK2 and metastatic malignant neoplasm in the lymph nodes: In the univariate survival analysis, high RIOK2 expression (HR = 2.878; P < 0.001), high NOB1 expression (HR = 2.030; P = 0.001), tumour diameter (HR = 1.641, P = 0.021), TNM clinical stage (HR = 3.381; P < 0.001), lymph node metastasis (HR = 1.795; P = 0.010) and differentiation (HR = 2.172; P < 0.001) were associated with the overall survival rate (Table 2).