RIOK1 and RIOK2 are overexpressed in glioblastoma cells in an Akt-dependent manner, and down-regulated expression of RIOK1 or RIOK2 disrupts Akt signalling and causes cell cycle exit, apoptosis, and chemosensitivity in glioblastoma cells by inducing p53 activity27. This evidence concerns the gene RIOK2 and glioblastoma.