KEAP1 and hepatocellular carcinoma: To determine whether the p62–Keap1–Nrf2 pathway contributes to metabolic reprogramming in tumour cells, we expressed FLAG-tagged wild-type p62, phosphorylation-mimetic p62 (S351E) or phosphorylation-defective p62 (S351A) in Huh7, a human HCC cell line.