MYC and breast carcinoma: Both HUR and let-7 have been reported to bind to the 3'-element, thus destabilizing MYC mRNA level and repressing its expression.55, 56 In our study, we found that forced p62 expression significantly delayed half-life of MYC mRNA in breast cancer cell lines (Figure 7B and Supplementary Figure 8), indicating a role of p62 in stabilizing MYC mRNA.