In the present study, we found that SalA treatment effectively protected rats against HFD-induced liver injury, as indicated by following results: 1) SalA conferred protection against HFD- or PA-induced hepatic steatosis, inflammation and oxidative stress; and 2) the protective effects of SalA were associated with the TXNIP/NLRP3 and TXNIP/ChREBP pathways. This evidence concerns the gene MLXIPL and fatty liver disease.