Furthermore, it should be mentioned that in recent studies, some polyphenols have been observed to play a role in inhibiting PPARγ expression and attenuating obesity in HFD-fed mice53; additionally, obesity, co-existing with NAFLD and sharing a common pathophysiology, has been considered an independent risk factor for NAFLD54, 55. The gene discussed is PPARG; the disease is metabolic dysfunction-associated steatotic liver disease.