Indeed, the onset of bleomycin-induced lung fibrosis in mice has been found to be primed by chronic alcohol abuse; the priming effect is considered to be the result of the reduced expression of the NRF2-dependent genes for GST theta 2 and the catalytic subunit of glutamate-cysteine ligase and of the increased expression of TGF-β1 (Sueblinvong et al. 2014a). This evidence concerns the gene NFE2L2 and alcohol abuse.