This is particularly evident in the liver, where NRF2 protects mice from carbon-tetrachloride-induced hepatic fibrosis (Xu et al. 2008) or fibrosis when fed a methionine- and choline-deficient diet (Chowdhry et al. 2010; Sugimoto et al. 2010; Zhang et al. 2010; Okada et al. 2012). Here, NFE2L2 is linked to fibrosis.