For the MetS is closely associated with glucose and lipid homeostasis, and the alteration of ANGPTL8/betatrophin has been reported to be involved in proliferation of pancreatic beta cells and regulation of glucose and lipid metabolism in mice6, 7, 8, ANGPTL8/betatrophin could be a strong candidate for prediction of future development of the MetS. This evidence concerns the gene ANGPTL8 and metabolic syndrome.