DNMT3A and neoplasm: We found that miR-122 was most significantly down-regulated among the four tumor-suppressive miRNAs analyzed in DDX3-knockdown HepG2 cells (Fig. 5g), which is consistent with the results that DDX3 knockdown induces most significant DNMT3A recruitment as well as hypermethylation status on promoter region of MIR122 (Figs 6c and 7c).