Also, enhanced methylated promoter regions of MIR200C (2.8- to 3.3-fold), MIR122 (6.5- to 9.0-fold) and MIR145 (1.6- to 2.2-fold) in DDX3-knockdown cells suggested enhancements of promoter methylation of these tumor-suppressive miRNAs (Fig. 7c). The gene discussed is DDX3X; the disease is neoplasm.