INS and prediabetes syndrome: Based on this data, we favour the following concept of organ crosstalk in prediabetes: MUHO might induce the development of fatty liver and organ crosstalk, which involves fetuin-A; in the presence of a fatty pancreas, this hepatokine could amplify the cellular crosstalk described in Fig. 5 and this might finally affect islet function and survival and therefore the capacity for compensatory insulin hypersecretion.