Of note, only a limited number of TGFBR1CA Lox/Lox; Cyp19-Cre female mice were obtained during the course of the experiment because TGFBR1CA Lox/+; Cyp19-Cre male breeders were also prone to testicular tumor formation at an early reproductive age (Figure S9), presumably due to Cyp19-Cre expression in the testis [52]. This evidence concerns the gene CYP19A1 and neoplasm of testis.