Interestingly, RIPK3-deficient mice had increased Wnt-β-catenin signaling shown by induction of genes important for IEC survival, proliferation and invasiveness (cMyc, Cox2 and Wisp1), and cell cycle progression (Cyclin B1, Cyclin D1, Cyclin E and p21) during colitis-associated CRC. This evidence concerns the gene PTGS2 and colitis.