Expression of genes involved in angiogenesis and mitogenic responsiveness, comprising the EGFR ligand Epiregulin (Ereg), matrix metalloproteinase 10 (Mmp10), and cyclooxygenase 2 (Cox2) were up-regulated in colon tumors of Ripk3−/− mice (Figure 4A). This evidence concerns the gene EREG and colonic neoplasm.