RIPK3 and adenocarcinoma: RIPK3-deficient animals with high-grade dysplasia and intra-mucosal adenocarcinomas had significantly more overall inflammation scores than WT animals (Figure 2C), which could also be appreciated by the increased colon thickness in the non-neoplastic colon (Figure 2D) and the enhanced tumor-underlying transmural inflammation seen in Ripk3−/− mice (Figure 2A; arrows).