RIPK3 and colorectal neoplasm: While WT colorectal adenomas showed mainly low-grade of dysplasia depicted by classic tubular structures and moderately distorted glands, Ripk3−/− colorectal neoplasms displayed markedly abnormal glandular proliferation with cribriform architecture indicative of a higher level of dysplasia and progression to well-differentiated intra-mucosal adenocarcinomas (Figure 2A and 2B).