Here we show that the upregulation of Stat3 activity during GBM CSC differentiation is consistent with higher levels of GFAP with respect to PDGFRα-depleted cells, which instead revealed a decrease of GFAP and NG2 expression and the early activation of neuronal marker MAP2a/b in proliferating cells [27]. This evidence concerns the gene PDGFRA and glioblastoma.