Accordingly Sakakini et al. reported that the nuclear expression of Egr1 is restricted to proliferating cells in high-grade gliomas, and in primary cultures of glioma stem-like cells, Egr1 contributes to stemness marker expression and proliferation by orchestrating a PDGF-AA-dependent growth stimulatory loop [28]. The gene discussed is EGR1; the disease is glioma.