Such hypothesis was further supported by the poorly impacted growth of leukemia cells when ASCT2 was silenced in HL-60 (see Figure 3F and 3G) and K-562 leukemia cells (Supplementary Figure S1A and S1B), a pattern contrasting with the net growth inhibitory effects resulting from complete Gln deprivation (compare no Gln condition in Figure 1A and ASCT2 siRNA in Figure 3G). Here, SLC1A5 is linked to leukemia.