Indeed, knockdown of Ezrin using siRNA strongly reduced PGE2-induced β-catenin-dependent transcription and abolished co-immunoprecipitation of Epac1 and β-catenin, indicating that indeed Ezrin is required for the Epac1 and β-catenin association in NSCLC cells. Here, RAPGEF3 is linked to non-small cell lung carcinoma.