The positive association between low IGF-1 with a low level of HDL-C and metabolic syndrome observed in this study suggests that a low IGF-1 level contributes to the increased risk of cardiovascular disease in obese children and adolescents, implying that IGF-1 may be an important biomarker for clinicians to identify subjects at risk for early cardiovascular disease in obese children. Here, IGF1 is linked to cardiovascular disorder.