Similarly, the over-expression of p16 was also reported in BD [13, 23–30]; however, only few studies have focused on a correlation of the expression of p16 with the HPV status in Bowen’s disease and when this was performed, a correlation between p16 expression with the presence of mucosal HPV types only was studied [13, 23, 24]. This evidence concerns the gene CDKN2A and Bowen disease of the skin.