As done for the Human body map RNA-seq datasets, the motif inclusion of NLS and NES was quantified across a panel of breast cancer datasets comparing estrogen-positive tumors (ER+), triple negative tumors, HER2-positive tumors (HER2+) and benign tumors [59] (Additional file 4: Figures S2–S3). This evidence concerns the gene ERBB2 and benign neoplasm.