The models revealed systemic IL-6 to be the main predictor in all groups (IS + IR + type 2 diabetes mellitus) (β = −0.3, p = 0.03), including the IR (β = −0.4, p = 0.05) and non-diabetic groups (IS + IR) (β = −0.4, p = 0.01), explaining 10%, 20% and 20% of SC differentiation, respectively (data not shown). The gene discussed is IL6; the disease is type 2 diabetes mellitus.