Interestingly, VGCCs are known to have a number of protein interaction sites along their amino acid sequence, which allows for interaction with proteins that influence gene transcription such as CREB, NFAT, calmodulin and MEK (see the review by Barbado et al. 2009), therefore enabling ion channels to indirectly control transcription of genes that are known to be involved in cancer development and progression (Xiao et al. 2010; Mancini and Toker 2009; Berchtold and Villalobo 2014). The gene discussed is MAP2K7; the disease is cancer.