NFE2L2 and neoplasm: Similarly, other studies have shown that crocin could arrest the tumor cell cycle and induce apoptosis by inhibition of the expression of Bcl-2, survivin, cyclin D1, and lactate dehydrogenase A (LDHA) or by up-regulation the expression and activity of Bax and nuclear factor erythroid 2-related factor 2 (Nrf2), and by inhibition of the telomerase activity [10, 19, 20, 32, 33].