Multivariate analysis performed for cGRFS corrected for covariates for both GVHD and relapse showed that cGRFS is significantly improved in recipients of KIR genotype-matched transplants as compared to the recipients of KIR genotype-mismatched transplants in both discovery and validation cohorts (p = 0.002 and 0.026 respectively; Fig 5A and 5B, left panel). This evidence concerns the gene KIR3DL1 and graft versus host disease.