ChIP assays revealed a role for TAF4b in directly occupying the promoters of a number of genes that are known “master regulators” of oogenesis including the transcription factors Figlα and Nobox. Remarkably, Figlα and Nobox mutant ovaries strongly phenocopy Taf4b-deficient ovaries with Figlα-deficient mice experiencing germ cell death immediately after birth [12], and Nobox-deficient mice exhibiting cyst breakdown defects as well as primordial follicle loss [13,15]. The gene discussed is NOBOX; the disease is cyst.