SNCA and Parkinson disease: The SNCA TSS2-1 sgRNA was capable of reducing alpha-synuclein transcript (Fig. 1d) and protein (Fig. 1e) levels across multiple cell lines, including HEK293T, as well as the PD-relevant dopaminergic neuroblastoma cellular models, BE(2)-M17 and SH-SY5Y, examined by qRT-PCR and ELISA, respectively.