As alpha-synuclein is well-validated as a central mediator of PD pathogenesis1, 2, 3, 4, 5, 6, 7, 8, 9, 10, we first evaluated the utility of dCas9 in executing transcriptional regulation of neurodegenerative disease-related genes by targeting the SNCA gene. This evidence concerns the gene SNCA and Parkinson disease.