CDK4 and B-cell acute lymphoblastic leukemia: As shown in Figure 5, mRNA levels of p63 and several transcriptional targets of c-Myc, including CDK4, EZH2 and eIF-2α, are concomitantly up-regulated in human B-cell acute lymphoblastic leukemia specimens, while mRNA levels of MM1 and c-Myc remain largely unchanged, suggesting that elevated p63α may stimulate c-Myc transactivity in some cancer types, such as B-cell acute lymphoblastic leukemia.