SDCBP and neoplasm: At present, we have a clearer appreciation of how MDA-9/Syntenin facilitates tumor cell invasion from a primary tumor site [7–11], i.e., how this protein regulates autonomous and non-autonomous signaling of tumor cells to degrade the extracellular matrix (ECM) [7–9, 29–32], promotes migration [29–31, 33], induces angiogenesis [11, 33] and facilitates escape from the primary tumor niche.