AGO4 and infection: (2013) showed that Pst DC3000 infection of Arabidopsis represses RdDM genes, such as AGO4, AGO6, NRPD2, and RDR1, which offers a plausible explanation as to why Pst DC3000 induces DNA hypo‐methylation in Arabidopsis (Pavet et al., 2006; Dowen et al., 2012).