However, CYP2R1 (p=0.034), CYP8B1 (p=0.002), CYP39A1 (p<0.001), CYP46A1 (p<0.001) and CYP51A1 (p=0.001) each demonstrated significantly reduced expression in paired lymph node metastasis compared to Dukes C (stage 3) colorectal cancer. The gene discussed is CYP8B1; the disease is colorectal cancer.