While weekly CY+TLRa treatment predictably resulted in partial depletion of tumor-reactive IFNγ-secreting T-cells (Figure 3), such treatment also produced an even greater body wide progressive depletion of Tregs, especially intratumorally, where as early as c2d3 Foxp3+ T-cells were virtually undetectable (Figure 4). The gene discussed is IFNG; the disease is neoplasm.