ITGAM and tuberculosis: When Gr1dim and Gr1high subsets of CD11b+Gr1+ splenocytes were isolated from CY+TLRa-treated TB mice on c2d3 of treatment, it was observed that granulocytic CD11b+Gr1hi splenocytes (Figure 5D) had no inhibitory effect upon 4T1-f growth in vitro, even with the addition of CpG alone or CpG+IFNγ to culture (Figure 5A-5C column 4).