Finally, a single TLRa (CpG given i.p. or s.c. midcycle) was sufficient for CY+TLRa to permanently eradicate a subset of advanced tumor models including CT26 and 4T1 (Supplemental Figure S3C and data not shown), whereas other models such as Panc02, KC (pancreatic), and C57mg (breast) only achieved transient rather than permanent regressions unless both CpG and pIC were administered (data not shown). The gene discussed is CALCA; the disease is neoplasm.