NTRK1 and neoplasm: Interestingly, two tested agents, 5-FU and the receptor tyrosine kinase inhibitor sunitinib, were well tolerated in conjunction with TLRa and furthermore depleted splenic MDSCs in the 4T1 and CT26 models even more than CY (data not shown), yet in contrast to CY+TLRa did not reverse tumor progression (Supplemental Figure S2C and data not shown).