CD4 and neoplasm: Although IFNγ-producing, CD4+ and CD8+ host T-cells were crucial for the effectiveness of the treatment (Figure 2A), and although tumor-specific IFNγ-producing T-cells were present in treated mice (Figure 3A-3B), isolated T-cells did not display demonstrably sustained tumoricidal nor tumoristatic effects even after in vitro exposure to exogenous IFNγ and TLRa (Figure 5).