In the present study, therefore, we systematically analyzed the association of 43 SNPs of ten key NER pathway genes (ERCC1, ERCC2, ERCC3, ERCC4, ERCC5, ERCC6, ERCC8, XPA, XPC, and DDB2) with survival of GC patients to investigate whether NER pathway polymorphisms could serve as potential biomarkers for GC prognosis. This evidence concerns the gene ERCC3 and gastric cancer.