AKT1 and central nervous system cancer: Progesterone dependent PI3K/Akt/mTOR signaling modulation was observed in glioma cells in vitro although the nPGR was blocked by RU486, an inhibitor of the nPGR, suggesting that the nongenomic action of progesterone via MAPRs has an important role in the progesterone responsiveness of glioma cells [8].