A randomized, controlled phase III trial (CS21) has shown that patients receiving either low or high dose of the GnRH antagonist degarelix (Firmagon®) subcutaneously for locally advanced or high-risk prostate cancer (240 mg followed by either 80 or 160 mg monthly, respectively) were more likely to reach castration levels of testosterone by day 3 post treatment than those receiving a GnRH agonist (leuprolide; intramuscular; 7.5 mg monthly), with 95.5–96.1 % patients vs. 0 % patients, respectively [51]. Here, GNRH1 is linked to prostate carcinoma.