In addition to the development of bone osteolytic lesions, TGFβ also contributes to the development of metastases by directing cells to specific tissues and by enhancing the extravasation of breast cancer cells into the lung parenchyma [262], by inducing expression of cyclooxygenase-2 (COX2), epidermal growth factor receptor (EGFR), and angiopoietin-like 4 (ANGPTL4), and promoting development of lung metastasis [263]. The gene discussed is PTGS2; the disease is breast carcinoma.