LY2109761 inhibits both Smad-dependent and -independent TGFβ responses and attenuates TGFβ-induced cell migration, invasion, and tumorigenicity in colon adenocarcinoma [326] and decreases liver metastases and prolonged survival in a murine pancreatic cancer model [327]. The gene discussed is TGFB1; the disease is colon adenocarcinoma.