In addition to the development of bone osteolytic lesions, TGFβ also contributes to the development of metastases by directing cells to specific tissues and by enhancing the extravasation of breast cancer cells into the lung parenchyma [262], by inducing expression of cyclooxygenase-2 (COX2), epidermal growth factor receptor (EGFR), and angiopoietin-like 4 (ANGPTL4), and promoting development of lung metastasis [263]. This evidence concerns the gene TGFB1 and breast carcinoma.