Some studies revealed that an infusion of oxaliplatin in CRC patients caused the release of inflammatory cytokines such as interleukin 6(IL-6) and tumor necrosis factor alpha (TNF-α) [25, 26] Interleukin-1beta (IL-1 β), IL-6 and TNF-α (proinflammatory cytokines) and prostaglandin E2 (PGE2) as an eicosanoid develop neuropathic and inflammatory pain by their direct and indirect impact on the central and peripheral nervous systems (including DRG neurons, and glial cells) [9] . Here, TNF is linked to colorectal carcinoma.